FRDD
Forensically-Relevant Drug Database
N-Pyrrolidino Protonitazene
Description
Preferred Drug Name
N-Pyrrolidino Protonitazene
Brief Description
N-Pyrrolidino protonitazene is a novel synthetic opioid bearing structural resemblance to protonitazene, N-pyrrolidino etonitazene, and other nitazene (2-benzylbenzimidazole) analogues and is an isomer of N-pyrrolidino isotonitazene. In January 2023, N-pyrrolidino protonitazene was detected for the first time in the United States. Limited information regarding the pharmacology of N-pyrrolidino protonitazene is currently known. Based on structural similarity, N-pyrrolidino protonitazene is expected to exhibit similar adverse effects to other nitazene analogues and is not explicitly scheduled in the United States.
Structure
Nomenclature
Formal Name (IUPAC)
5-nitro-2-[(4-propoxyphenyl)methyl]-1-(2-pyrrolidin-1-ylethyl)benzimidazole
Synonyms
Protonitazepyne
Identifiers
CAS Numbers
3038401-95-2
Chemistry
Chemical Formula
C23H28N4O3
Molecular Mass
408.49
Molecular Ion
408
Exact Mass
409.2234
SMILES
CCCOC(C=C1)=CC=C1CC2=NC3=CC([N+]([O-])=O)=CC=C3N2CCN4CCCC4
InChI String
InChI=1S/C23H28N4O3/c1-2-15-30-20-8-5-18(6-9-20)16-23-24-21-17-19(27(28)29)7-10-22(21)26(23)14-13-25-11-3-4-12-25/h5-10,17H,2-4,11-16H2,1H3
InChI Key
KCRWXNIIXGBPID-UHFFFAOYSA-N
Classifications
Drug Class
Opioid
Structural Classes
Nitazene Analogue
Drug Types
Parent Drug
GCMS Analytics
Lab
CFSRE (Willow Grove, PA)
Comments
| Sample Preparation: | Sample: Acid / base extraction Standard (above): Diluted in methanol |
| Instrument: | Agilent 5975 Series GC/MSD |
| Methods: | http://www.cfsre.org/nps-discovery/monographs |
Images
Fragments
84
107
42
107
42
HRMS Analytics
Lab
CFSRE (Willow Grove, PA)
Comments
| Sample Preparation: | Acid / base extraction |
| Instrument: | Sciex TripleTOF® 5600+ LC-QTOF-MS |
| Methods: | https://www.cfsre.org/nps-discovery/monographs |
Images
Fragments
98.0956
409.223
409.223
Drug Origins and Uses
Drug Origins and Uses
Illicit, Synthetic
Biological Effects
Biological Effects
Analgesic, Depressant
Target Receptor or Neurotransmitter
Target Receptor or Neurotransmitter
MOR
Pharmacodynamics
Pharmacodynamics
Agonist
Toxicology Postmortem Fatal
Source
The American Journal of Forensic Medicine and Pathology
Title
New and Emerging “Nitazene” Analogues Appearing in Medicolegal Death Investigations N-Pyrrolidino Protonitazene and N-Desethyl Isotonitazene
Reference Link
Toxicology Data Clinical Nonfatal
Source
Drug Testing and Analysis
Title
Identification of N-pyrrolidino protonitazene in powders sold as heroin and associated with overdose clusters in Dublin and Cork, Ireland
Reference Link
Drug Control
US Controlled Substance Schedule
Schedule I
References
CFSRE
Cayman Chemical
UNODC
PubMed
PubChem
Analytical Literature
Source
National Forensic Laboratory
Title
N-Pyrrolidino Protonitazene (C23H28N4O3)
Reference Link
Published October 05, 2026
