FRDD
Forensically-Relevant Drug Database
Description
Preferred Drug Name
Brief Description
Dihydro-7-hydroxy mitragynine (“MGM-15”) is synthetic derivative of 7-hydroxy mitragynine. It is structurally similar to known kratom alkaloids and is the primary component in products being sold as “MGM-15”.1 Analysis of dihydro-7-hydroxy mitragynine is challenging due to the analytical conversion of dihydro-7-hydroxy mitragynine to mitragynine during GC-MS analysis. Dihydro-7-hydroxy mitragynine was first identified by our laboratory in September 2025 and confirmed after acquiring standard reference material.
Structure
Nomenclature
Formal Name (IUPAC)
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Chemistry
Chemical Formula
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Exact Mass
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InChI Key
HRMS Analytics
Lab
Comments
| Sample Preparation: | Toxicology Samples: Liquid-liquid extraction Drug Materials: Dilution of sample in mobile phase |
| Instrument: | Sciex TripleTOF® 5600+, Shimadzu Nexera XR UHPLC Sciex X500R, Sciex ExionLC |
| Column: | Phenomenex® Kinetex C18 (50 mm x 3.0 mm, 2.6 µm) |
| Mobile Phase: | A: Ammonium formate (10 mM, pH 3.0) B: Methanol/acetonitrile (50:50) Flow rate: 0.4 mL/min |
| Gradient: | Initial: 95A:5B; 5A:95B over 13 min; 95A:5B at 15.5 min |
| Temperatures: | Autosampler: 15 °C Column Oven: 30 °C Source Heater: 600 °C |
| Injection Parameters: | Injection Volume: 10 µL |
| QTOF Parameters: | TOF MS Scan Range: 100-510 Da Precursor Isolation: SWATH® acquisition (27 windows) Fragmentation: Collison Energy Spread (35±15 eV) MS/MS Scan Range: 50-510 Da |
Images
Fragments
385.2105
252.1592
174.0912
